Therapeutic indices in thalassemia major: association with bone mineral density - Payesh (Health Monitor)
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Volume 3, Issue 1 (JANUARY 2004)                   Payesh 2004, 3(1): 75-81 | Back to browse issues page

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Abdollah Shamshirsaz A.R, Bekheirnia M.R, Kamgar M, Tabatabaie S.M, Moradi Zirkuhi A, Bouzari N, et al . Therapeutic indices in thalassemia major: association with bone mineral density. Payesh 2004; 3 (1) :75-81
URL: http://payeshjournal.ir/article-1-823-en.html
Abstract:   (5554 Views)
Objective(s): To evaluate bone mineral density (BMD) in children and young adults with thalassemia and its potential risk factors.
Methods: Two hundreds and twelve thalassemic patients aged 10-20 were enrolled in the study. In all patients height, weight, body mass index, growth indices, pubertal development, calcium intake and serum ferritin were assessed. BMD was determined by dual-energy X-ray absorptiometry (Lunar).  BMD z scores between -1 and -2.5 were identified as low bone mass and z scores less than -2.5 were considered severely low bone mass.
Results: Prevalence of severely low bone mass was 50.7% in lumbar spine, 10.8% in femur and 7.9% in both areas. There was no statistically significant between males and females. Low bone mass was observed in 39.5% and 37.5% of patients in lumbar and femoral areas. Patients with severely low bone mass in lumbar spine were older than the others (P<0.00 I).
Conclusion: The data confirm significant reductions in BMD in Iranian thalassemic patients. Further research is needed to identify risk factors and preventive methods recommend.
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type of study: Descriptive |
Accepted: 2018/11/28 | Published: 2004/01/15

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