Volume 18, Issue 2 (March-April 2019)
Payesh 2019, 18(2): 149-159 |
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Zobdeh P, Sardari D. Examination of logistic mathematical models and providing an appropriate response for treatment of cancerous tumors. Payesh 2019; 18 (2) :149-159
URL: http://payeshjournal.ir/article-1-1031-en.html
URL: http://payeshjournal.ir/article-1-1031-en.html
1- Science and Research Campus, Azad University, Tehran, Iran
Abstract: (3523 Views)
Objective (s): In this research, we examined the different mathematical models of cancerous tumor growth and compared several models to calculate and evaluate the response of the growth logistic model to the specific growth rate conditions.
Objective (s): In this research, we examined the different mathematical models of cancerous tumor growth and compared several models to calculate and evaluate the response of the growth logistic model to the specific growth rate conditions.
Methods: The growth rate was simulated by considering it as a function of time (linear, exponential growth, and linear growth-decay). Responses were obtained by using Range-Kutta's numerical solution method.
Results: The general response is the logistic growth curve, but the external factors in the treatment can be controlled to optimally respond of model.The optimal conditions for controlling the growth of the tumor obtained by the linear growth rate-decay for the constants k1=0.1 and k2=1.
Conclusion: Solid tumor structure is associated with a decrease in the stage of growth of the cells prior to angiogenesis. Increasing lagging agents such as accelerating immunological response during exponential growth functions can control tumor growth. The numerical results obtained in this study can provide an optimal therapeutic strategy by reducing the volume of primary cancer by calculating angiogenic inhibitors. Also, by analyzing pathology, mechanical properties of tumor growth, cellular adaptation and therapeutic resistance, we can overcome some of the previous constraints in the general growth model.
Key Words: Treatment, Tumor growth, Cancer, logistic mathematical models, Control
Objective (s): In this research, we examined the different mathematical models of cancerous tumor growth and compared several models to calculate and evaluate the response of the growth logistic model to the specific growth rate conditions.
Methods: The growth rate was simulated by considering it as a function of time (linear, exponential growth, and linear growth-decay). Responses were obtained by using Range-Kutta's numerical solution method.
Results: The general response is the logistic growth curve, but the external factors in the treatment can be controlled to optimally respond of model.The optimal conditions for controlling the growth of the tumor obtained by the linear growth rate-decay for the constants k1=0.1 and k2=1.
Conclusion: Solid tumor structure is associated with a decrease in the stage of growth of the cells prior to angiogenesis. Increasing lagging agents such as accelerating immunological response during exponential growth functions can control tumor growth. The numerical results obtained in this study can provide an optimal therapeutic strategy by reducing the volume of primary cancer by calculating angiogenic inhibitors. Also, by analyzing pathology, mechanical properties of tumor growth, cellular adaptation and therapeutic resistance, we can overcome some of the previous constraints in the general growth model.
Key Words: Treatment, Tumor growth, Cancer, logistic mathematical models, Control
type of study: Descriptive |
Accepted: 2019/05/4 | ePublished ahead of print: 2019/05/11 | Published: 2019/06/9
Accepted: 2019/05/4 | ePublished ahead of print: 2019/05/11 | Published: 2019/06/9
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