Safety and efficacy of increasing serum vitamin D by milk fortification - Payesh (Health Monitor)
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Volume 3, Issue 1 (JANUARY 2004)                   Payesh 2004, 3(1): 27-38 | Back to browse issues page

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Larijani B, Shaikholeslam R, Adibi H, Shafaie A, Maghbooli Z, Mohammad-zadeh N et al . Safety and efficacy of increasing serum vitamin D by milk fortification. Payesh 2004; 3 (1) :27-38
URL: http://payeshjournal.ir/article-1-817-en.html
Abstract:   (7409 Views)
Objective(s): Deficiencies in calcium and vitamin D intakes are involved in the etiology of osteoporosis, and health authorities recommend that the population consume a diet providing sufficient calcium and vitamin D. We studied the safety and efficacy of milk fortified with vitamin 03.
Methods: We conducted a double-blind, placebo-controlled trial of fortified milk (600 JU/I vitamin 03) compared to unfortified milk in 216 subjects (aged 2-98 years). Serum 25-hydroxyvitamin D [25(0H) D], calcium, creatinine, PTH were measured at baseline and after intervention. 109 subjects ingested 400 mL fortified milk with 240 JU vitamin D, and l 07 subjects ingested a control milk daily for 8 wk.
Results: After subjects consumed fortified milk for 8 wk, serum 25(0H) D3 concentrations increased by
33%, and serum parathyroid hormone concentrations decreased by 40% compared with baseline; control subjects had a decrease of 7% in 25(0H) D and no significant change in serum parathyroid hormone. In the fortified group, serum 25(0H) D increased by 13 nmol/1 from 39.94 nmol/1 to 53.37 nmol/1. In the control group, serum 25(0H) D felt by 3 nmol/1 from 43.11 nmol/1 to 39 .9 nmol/1.
Conclusion: Vitamin D-fortified milk may assist in maintaining vitamin D status in the general population.
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type of study: Descriptive |
Accepted: 2018/11/28 | Published: 2004/01/15

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