Ethics code: IR.SUMS.NUMIMG.REC.1394.S597
1- Medical Sciences Branch, Islamic Azad University, Firoozabad, Iran
2- Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Midwifery and Reproductive Health, School of Nursing and Midwifery; Iran University of Medical Sciences, Tehran, Iran
2- Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Midwifery and Reproductive Health, School of Nursing and Midwifery; Iran University of Medical Sciences, Tehran, Iran
Abstract: (52 Views)
Objective(s): Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women. It can lead to physical, mental health, and premenstrual symptoms. Recognizing the symptoms of the syndrome is crucial for early diagnosis, which greatly contributes to the overall well-being of those affected. This study aimed to examine the effects of polycystic ovary syndrome on general health and premenstrual symptoms.
Methods: In 2017, we conducted a case-control study on 340 women between 15 and 20 years. The participants were selected from clinics and schools in Shiraz by cluster random sampling. We divided them into two groups: 170 patients and 170 healthy individuals. The study involved completing questionnaires related to demographic characteristics, Goldberg's general health, Rotterdam Polycystic Ovary Diagnosis Criteria, and physical and mental symptoms of premenstrual syndrome. Data analysis was performed using descriptive statistics, independent t-tests, and chi-square tests with SPSS version 18 software, and a significance level of 0/05 was considered.
Results: The analysis of data showed that the PCOS group had significantly higher average weight and body mass index (P < 0.001). Premenstrual edema was more prevalent in the PCOS group (P = 0.003), and they also had lower scores on There were no significant differences in height, age at menarche, and GHQ score between the two groups.
Conclusion: The health of women with polycystic ovary syndrome should be carefully and comprehensively considered. Physical issues such as being overweight, obesity, and hirsutism, as well as menstrual disorders, can gradually affect mental health in the future. Therefore, it is important to pay more attention to the lifestyle and symptoms of the syndrome from a young age.
type of study: Case-control |
Subject:
Reproductive Health
Received: 2024/08/18 | Accepted: 2025/04/19 | ePublished ahead of print: 2025/10/21
Received: 2024/08/18 | Accepted: 2025/04/19 | ePublished ahead of print: 2025/10/21
References
1. Polycystic ovary syndrome 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome#:~:text=Key%20facts,a%20leading%20cause%20of%20infertility
2. Stener-Victorin E, Teede H, Norman RJ, Legro R, Goodarzi MO. Polycystic ovary syndrome. Nat Nature Reviews. Disease Primers 2024;10 :27 [DOI:10.1038/s41572-024-00511-3]
3. Deswal R, Narwal V, Dang A, Pundir CS. The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. Journal of Human Reproductive Sciences 2020;13:261-7 [DOI:10.4103/jhrs.JHRS_95_18]
4. Yang J, Chen C. Hormonal changes in PCOS. Journal Endocrinol 2024;261:e230342 [DOI:10.1530/JOE-23-0342]
5. Lee IT, Rees J, King S, Kim A, Cherlin T, Hinkle S, Mumford SL, Dokras A. Depression, Anxiety, and Risk of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Longitudinal Study. The Journal of Clinical Endocrinology and Metabolism 2024:2:256 [DOI:10.1210/clinem/dgae256]
6. Cupino-Arcinue DJ, Banal-Silao MJ. Prevalence of Anxiety and Depression among PCOS Patients Seen in a Tertiary Government Hospital Using the Hospital Anxiety and Depression Scale - English/Pilipino Version (HADS/HADS-P). Acta Medica Philippina 2024;58:29-38 [DOI:10.47895/amp.v58i11.8977]
7. Dybciak P, Raczkiewicz D, Humeniuk E, Powrózek T, Gujski M, Małecka-Massalska T, Wdowiak A, Bojar I. Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine 2023;12:6446 [DOI:10.3390/jcm12206446]
8. Jiang L, Yang D, Li Y, Yuan J. The Influence of Pubertal Development on Adolescent Depression: The Mediating Effects of Negative Physical Self and Interpersonal Stress. Frontiers in Psychiatry 2021;12:786386 [DOI:10.3389/fpsyt.2021.786386]
9. Pfeifer JH, Allen NB. Puberty Initiates Cascading Relationships Between Neurodevelopmental, Social, and Internalizing Processes Across Adolescence. Biological Psychiatry 2021;89:99-108 [DOI:10.1016/j.biopsych.2020.09.002]
10. Ozcan Dag Z, Oguzturk O, Isik Y, Turkel Y, Bulcun E. Personality Profile in Patients with Polycystic Ovary Syndrome. Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology 2015;31:540-2 [DOI:10.3109/09513590.2015.1018162]
11. Stefanaki K, Karagiannakis DS, Raftopoulou M, Psaltopoulou T, Paschou SA, Ilias I. Obesity and Hyperandrogenism are Implicated with Anxiety, Depression and Food Cravings in Women with Polycystic Ovary Syndrome. Endocrine 2023;82:201-208 [DOI:10.1007/s12020-023-03436-1]
12. Ranjbaran M, Omani Samani R, Almasi-Hashiani A, Matourypour P, Moini A. Prevalence of premenstrual syndrome in Iran: A systematic review and meta-analysis. International Journal of Reproductive Biomedicine 2017;15:679-86 [DOI:10.29252/ijrm.15.11.679]
13. Al Sabbah H, Al Mutawa N, Assaf EA. Prevalence of premenstrual syndrome and its associations with dietary and other lifestyle factors among university female students in Dubai: A cross-sectional study. Women's Health (Lond) 2024;20:17455057241260026 [DOI:10.1177/17455057241260026]
14. Imai A, Ichigo S, Matsunami K, Takagi H. Premenstrual syndrome: management and pathophysiology. Clinical and Experimental Obstetrics & Gynecology 2015;42:123-8 [DOI:10.12891/ceog1770.2015]
15. Gurkan DY, Biligili N. Prevalence of Premenstrual Syndrome Among University Students: Associated Factors and Comfort Level. Bezmialem Science 2022;10:44-52 [DOI:10.14235/bas.galenos.2020.5441]
16. Tehrani FR, Simbar M, Tohidi M, Hosseinpanah F, Azizi F. The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study. Reproductive Biology and Endocrinology 2011;9:39 [DOI:10.1186/1477-7827-9-39]
17. Goldberg D, Williams, P. A User's Guide to the General Health Questionnaire. 1st Edition, Nfer-nelson: United Kingdom, 1988
18. Ebrahimi A, Molavi H, Musavi A. Psychometric Properties and Factor Structure of General Health Questionnaire 28 (GHQ-28) in Iranian Psychiatric Patients. Journal of Research in Behavioural Sciences 2007;5:5-12
19. Smet ME, McLennan A. Rotterdam criteria, the end. Australasian Journal of Ultrasound in Medicine 2018;21:59-60 [DOI:10.1002/ajum.12096]
20. Ramezani Tehrani F, Minooee S, Simbar M, Azizi F. A Simpler Diagnostic Method to Assess Hirsutism in the Iranian Population: Based on Modified Ferriman- Gallwey Scoring System. Iranian Journal of Endocrinology and Metabolism 2013;15:303-10
21. López-Estebaranz JL, Herranz-Pinto P, Dréno B. Consensus-Based Acne Classification System and Treatment Algorithm for Spain. Actas Dermo-Sifiliograficas 2017;108:120-31 [DOI:10.1016/j.ad.2016.10.001]
22. Mohapatra I, Samantaray SR. BMI and Polycystic Ovary Syndrome: Demographic Trends in Weight and Health. Cureus 2024;16:e55439 [DOI:10.7759/cureus.55439]
23. Zhou X, Hu Y, Yang Z, Gong Z, Zhang S, Liu X, et al. Overweight/Obesity in Childhood and the Risk of Early Puberty: A Systematic Review and Meta-Analysis. Frontiers in Pediatrics 2022;10: 795596 [DOI:10.3389/fped.2022.795596]
24. Nilsson O, Weise M, Landman EB, Meyers JL, Barnes KM, Baron J. Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits. Endocrinology 2014;155:2892-9 [DOI:10.1210/en.2013-2175]
25. Sheikhi V, Bonyadi S, Heidari Z. Causes of Short Stature in Children Referred to a Tertiary Care Center in Southeast of Iran: 2018-2020. Journal of Pediatrics Review. 2022;10:9 [DOI:10.32598/jpr.10.1.980.1]
26. Satoh M, Hasegawa Y. Factors affecting prepubertal and pubertal bone age progression. Front Endocrinol (Lausanne) 2022;13:967711 [DOI:10.3389/fendo.2022.967711]
27. Eledath Kolasseri A, Sivaraman J, Ramasamy T. Assessment of factors related to poly cystic ovarian syndrome - A comparative and correlational study. Journal of Psychosomatic Obstetrics & Gynecology 2024;45:2297166 [DOI:10.1080/0167482X.2023.2297166]
28. Szefler L, Szybiak-Skora W, Sadowska-Przytocka A, Zaba R, Wieckowska B, Lacka K. Metformin Therapy for Acne Vulgaris: A Meta-Analysis. Pharmaceuticals (Basel) 2024;17:728 [DOI:10.3390/ph17060728]
29. Vasam M, Korutla S, Bohara RA. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports 2023;36:101578 [DOI:10.1016/j.bbrep.2023.101578]
30. Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, et al. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduction and Targeted Therapy 2023;8:375 [DOI:10.1038/s41392-023-01608-z]
31. Pinto J, Cera N, Pignatelli D. Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review. Journal of Endocrinological Investigation 2024;47:1-22 [DOI:10.1007/s40618-024-02329-y]
32. Vatier C, Christin-Maitre S. Epigenetic/circadian clocks and PCOS. Human Reprodoctive 2024;39:1167-75 [DOI:10.1093/humrep/deae066]
33. Almahareeq M, Hamdan M, Vanoh D, Shawarb N, Herbawi J, Shawar E, et al. Comparison of premenstrual symptoms, psychological well-being, and nutritional status between Palestinian women with and without polycystic ovarian syndrome: a case-control study. BMC Women's Health 2024;24:360 [DOI:10.1186/s12905-024-03210-z]
34. Kite C, Lahart I M, Randeva H S, Kyrou I . The Influence of Polycystic Ovary Syndrome (PCOS) and Other Related Factors upon Health-Related Quality of Life in Women of Reproductive Age: A Case-Control Study. Women's Reproductive Health 2024;11:644-666 [DOI:10.1080/23293691.2023.2293968]
35. Lu KT, Ho YC, Chang CL, Lan KC, Wu CC, Su YT. Evaluation of Bodily Pain Associated with Polycystic Ovary Syndrome: A Review of Health-Related Quality of Life and Potential Risk Factors. Biomedicines 2022; 10:3197 [DOI:10.3390/biomedicines10123197]
36. Kataoka J, Olsson M, Lindgren E, Larsson I, Schmidt J, Benrick A, et al. Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome. Scientific Reports 2024;14:13495 [DOI:10.1038/s41598-024-63166-w]
37. Alur-Gupta S, Dokras A, Cooney LG. Management of polycystic ovary syndrome must include assessment and treatment of mental health symptoms. Fertility Sterility 2024;121:384-99 [DOI:10.1016/j.fertnstert.2024.01.018]
38. Elghobashy M, Lau GM, Davitadze M, Gillett CDT, O'Reilly MW, Arlt W, et al. Concerns and expectations in women with polycystic ovary syndrome vary across age and ethnicity: findings from PCOS Pearls Study. Frontiers in Endocrinology 2023;14:1175548 [DOI:10.3389/fendo.2023.1175548]
39. Lee S, Tejesvi MV, Hurskainen E, Aasmets O, et al. Gut bacteriome and mood disorders in women with PCOS. Human Reproductive 2024;39:1291-1302 [DOI:10.1093/humrep/deae073]
40. Yu L, Chen X, Bai X, Fang J, Sui M. Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients. Molecular Neurobiology 2023, Online ahead of print [DOI:10.1007/s12035-023-03744-7]
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