Volume 15, Issue 6 (November-December 2016)
Payesh 2016, 15(6): 653-661 |
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Fatemeh Naghizadeh mooghari, Kamran Guity, Bahareh Sedaghatikhayat, Behzad Laamerad, Fereidoun Azizi, Maryam S Daneshpour et al . Familial hypercholesterolemia in Tehran lipid and glucose study: A cross- sectional study. Payesh 2016; 15 (6) :653-661
URL: http://payeshjournal.ir/article-1-140-en.html
URL: http://payeshjournal.ir/article-1-140-en.html
Fatemeh Naghizadeh mooghari1 
, Kamran Guity2 , Bahareh Sedaghatikhayat2 , Behzad Laamerad1 , Fereidoun Azizi2 , Maryam S Daneshpour3 , Maryam Daneshpour 3
, Kamran Guity2 , Bahareh Sedaghatikhayat2 , Behzad Laamerad1 , Fereidoun Azizi2 , Maryam S Daneshpour3 , Maryam Daneshpour 3
1- Faculty of Basic Sciences, Payam Noor University, Share Rey, I. R. Iran
2- Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Behesh University of Medical Sciences, Tehran, Iran
2- Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Behesh University of Medical Sciences, Tehran, Iran
Abstract: (3480 Views)
bjective (s): Familial hypercholesterolemia (FH) is one of the most common hereditary disorders in lipid metabolism that is distinguished by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) and cholesterol, can be considered tendon xanthomas and raised risk of premature coronary heart disease (CHD). This study aimed to assess the association between rs2228671 polymorphisms in the LDLR gene with familial hypercholesterolemia in a sample of Tehran Lipid and Glucose Study.
Methods: This was a cross-sectional study in order to examine the association between rs2228671 common polymorphism of LDL-R gene with FH. The study sample consisted of 15005 participants of Tehran Lipid and Glucose Study. Genomic samples of the cases were extracted and the polymorphism of the considered gene was determined by the Tetra Primer ARMS-PCR method. The findings were analyzed by SPSS, FBAT, PLINK, PROGENY and POWER MARKER.
Results: In all 206 cases (in 22 families) were identified. The results showed that there was no significant association between rs2228671 and FH disease (P=0.70). The minor allele frequency of T allele measured was 0.1016. No individuals carrying TT genotype were found in this population.
Conclusion: The findings indicated that cases with rs2228671 polymorphisms had lesser minor allele frequency compared with other alleles. It seems that the absence of TT genotype can indicate protective role of T allele against familial hypercholesterolemia and cardiovascular diseases.
Methods: This was a cross-sectional study in order to examine the association between rs2228671 common polymorphism of LDL-R gene with FH. The study sample consisted of 15005 participants of Tehran Lipid and Glucose Study. Genomic samples of the cases were extracted and the polymorphism of the considered gene was determined by the Tetra Primer ARMS-PCR method. The findings were analyzed by SPSS, FBAT, PLINK, PROGENY and POWER MARKER.
Results: In all 206 cases (in 22 families) were identified. The results showed that there was no significant association between rs2228671 and FH disease (P=0.70). The minor allele frequency of T allele measured was 0.1016. No individuals carrying TT genotype were found in this population.
Conclusion: The findings indicated that cases with rs2228671 polymorphisms had lesser minor allele frequency compared with other alleles. It seems that the absence of TT genotype can indicate protective role of T allele against familial hypercholesterolemia and cardiovascular diseases.
type of study: Descriptive |
Accepted: 2016/05/10 | ePublished ahead of print: 2016/09/6 | Published: 2000/11/15
Accepted: 2016/05/10 | ePublished ahead of print: 2016/09/6 | Published: 2000/11/15
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